SPECTROPHOTOMETRIC DETERMINATION OF DRUGS HAVING PRIMARY AMINE GROUP WITH p-DIMETHYLAMINOCINNAMALDEHYDE
نویسندگان
چکیده
A new spectrophotometric method for the determination of each dapsone and metoclopramide HCl alone in two different tablet preparations is described. The reactions were completed at room temperature within 9 and 20 minutes, respectively. Maximum absorbances for the reaction products were observed at 548 nm (dapsone) and 553 nm (metoclopramide HCl). Beer’s law was obeyed over the concentration range of 4-12 μg/mL for dapson and 4-24 μg/mL for metoclopramide HCl. The molar absorptivity, Sandell sensitivity detection and quantification limits were also determined. The results of the methods were in good agreement with those obtained by reference methods cited in the literature. It was observed that the proposed method became suitable for quality control and routine analyses of tablets containing dapsone or metoclopramide HCl.
منابع مشابه
Flow-injection spectrophotometric determination of novalgin in pharmaceuticals using micellar medium.
A sensitive flow-injection (FI) procedure with spectrophotometric detection in a micellar medium is proposed for the determination of novalgin. The method is based on the instantaneous formation of a red-orange product (lambda(max) = 510 nm) after the reaction between novalgin and p-dimethylaminocinnamaldehyde (p-DAC) in a dilute acid medium. The sensitivity of this reaction was increased by a ...
متن کاملUse of N, N-diethyl-p-phenylenediamine sulphate for the spectrophotometric determination of some phenolic and amine drugs.
Spectrophotometric methods are proposed for the determination of drugs containing a phenol group [salbutamol sulphate (SLB), ritodrine hydrochloride (RTD), isoxsuprine hydrochloride (IXP)] and drugs containing an aromatic amine group [dapsone hydrochloride (DAP), sulfamethoxazole (SFM), and sulfadiazine (SFD)] in pharmaceutical dosage forms. The methods are based on coupling of N, N-diethyl-p-p...
متن کاملSensitive Indirect Spectrophotometric Method for Determination of H2-Receptor Antagonists in Pharmaceutical Formulations
A simple, accurate and sensitive spectrophotometric method has been developed and validated for determination of H2-receptor antagonists: cimetidine, famotidine, nizatidine, and ranitidine hydrochloride. The method was based on the oxidation of these drugs with cerium (IV) in presence of perchloric acid and subsequent measurement of the excess Ce (IV) by its reaction with p-dimethylaminocinnama...
متن کاملSimultaneous spectrophotometric analysis of aliphatic amines utilizing thermochromism of charge-transfer complexes with tetrabromophenolphthalein ethyl ester.
Aliphatic amines, such as n-hexylamine (primary), di-n-hexylamine (secondary) and tri-n-hexylamine (tertiary amine), react with tetrabromophenolphthalein ethyl ester molecules (TBPEH) to form reddish or red-violet charge-transfer complexes (CT complexes) in 1,2-dichloroethane (DCE). The absorption maxima of the CT complexes with all primary amines occur at around 560 nm, with secondary amines a...
متن کاملTitrimetric and Spectrophotometric Methods for the Determination of β-blockers in Pharmaceutical Dosage Form
Three new methods using titrimetric and spectrophotometry are described for the determination of Propranolol Hydrochloride (PPH) and Atenolol (AN) with potassium bromate as the oxidimetric reagent and acid dyes, Methyl orange and Indigo carmine. In direct titrimetric (method A), the drug is titrated directly with bromate in acid medium and in the presence of excess of bromide using methyl orang...
متن کامل